Take Route 22 to 378 south until expressway ends at the corner of Third and Wyandotte Streets. Turn right into Sayre Mansion driveway.
Take Bethlehem Exit, follow 412 North (turns into 3rd St) Proceed through the intersection of 3rd St. and Wyandotte. Make the first right into Sayre Mansion driveway.
For your GPS:
Use this address: 431 West Third Street, Bethlehem PA 18015